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KMID : 0861419990040010164
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Korean Journal of Nuclear Medicine Technology
1999 Volume.4 No. 1 p.164 ~ p.169
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이영희
오승준/유희재/김호성/신상기/조시만/정윤영
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Abstract
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Purpose: We evaluated a rapid preparation procedures for the labeling and quality control of
99mTc-ECD, MIBI and MAG3 using microwave heating and Sep-Pak cartridges.
Materials and Methods: 99mTc labeling of ECD, MIBI and MAG3 kit
preparation was performed according to the package inserts with microwave heating modification.
Heating time was 10∼15sec, and heating was performed with 3mm plastic bottle with screw cap to
prevent radiation contamination. Labeling efficiency was obtained with C18 or Alumina
N Sep-Pak cartridge.
Results: The radiochemical purity of 93∼96% for 99mTc-ECD and 95∼99% for
99mTc-MIBI was obtained using Alumina N Sep-Pak cartridge. The optimum irradiation
time of microwave method for 3ml 99mTc-labeled radiopharmaceutical solution was 10
sec for 99mTc-ECD, MIBI and 15 sec for 99mTc-MAG3. The
Alumina N Sep-PAk cartridge was used for checking of labeling efficiency of 99mTc-ECD,
and 99mTc-MIBI. The results of quality control data with
Sep-Pak cartridge were well correlation with TLC method data. The total preparation time
of these radiopharmaceutical was 5∼6min including quality control procedure.
Conclusion: This study demonstrates that radiopharmaceuticals preparation by microwave
heating and quality control by Sep-Pak cartridges can be efficiently utilized as an alternative
to the recommended method by manufacturer's manual.
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